Fertility Genetics Simplified

by Dr Agilan Arjunan, Fertility Specialist & Gynaecologist , KL Fertility Centre ( Malaysia)

The science involved in the treatment of infertility has rapidly advanced in the past few years . This advancement is clearly seen in the field of In-Vitro Fertilisation or IVF.

Current technology enables us to look into the genetics of human reproduction. Genetic testing also provides answers to infertility; and in some cases solutions.

Preimplantation Genetic Screening ( PGS)

IVF involves creating embryos in an IVF laboratory and replacing the embryo/embryos back into the womb.

Traditionally an embryo is graded based on its morphology ( external appearance under a microscope). The embryo/embryos with the best gradings is/are transferred back into the womb.

A morphologically-normal embryo with the best grading does not necessarily indicate that the embryo is genetically normal ( euploid embryo).

A genetically-normal embryo will lead to a successful pregnancy , assuming there are no other factors contributing to a failed embryo implantation or pregnancy.

Preimplantation genetic diagnosis (PGS) looks at the genetic normality of the embryo prior to an embryo transfer procedure.

Embryos are typically grown up to 3 to 6 days before the biopsy is performed.

Biopsy of the embryos are done when the embryo is either 3 days old or when they have reached Day 5 or 6 , known as a blastocyst.

Biopsy of the blastocyst is usually preferred because more cells are obtained from the embryo thus increasing the chances of the PGS to be performed successfully.

To be able to perform the biopsy, a small opening is made on the outer layer of the embryo , using either mechanical, chemical or laser technology.

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Hope for New Year : 2018

by Dr Agilan Arjunan, Fertility Specialist & Gynaecologist , KL Fertility Centre ( Malaysia)

Published in The Star Newspaper ( Fit For Life) https://www.star2.com/health/2018/03/10/theres-always-hope/

“The time is always right to do what is right” , “ Time waits for no one” , “ It takes time to build a castle” .

There are many proverbs about time . One thing for sure, time does fly and it’s already 2018 !

Time can be your good friend or enemy. For those with family and children, it’s fun to watch your little ones grow.

For those who are in the midst of their parenthood journey , time can be their greatest fear with each passing year.

There are many couples who kept their hopes high and persisted in their journey towards parenthood. They did achieve their goal .

I’m going to share some spirit-lifting real patient’s journey which will inspire your own journey.

Vaginismus

Mr & Mrs Jacob (not their real name) walked into my consultation room sometime in the late 2016.

They were a bit hesitant when they walked into my room. They slowly took their seats . They looked at each other probably deciding ‘who’ and ‘how’ to start the conversation.

I broke the silence by greeting them first ,“ Good morning, how can I help you?”

“ Doc, we have been married for 7 years,” the husband started. “We have not got a child yet” .

“ Have you both done any fertility test?” I asked.

Both of them looked at each other. It took a few seconds before his wife finally started talking.

“ We have not managed to have sex since our marriage” his wife said with some difficulty.

“ Well, if that’s the main reason, then the treatment is very easy !” I said with enthusiasm.

I could see that they both couldn’t believe my reply. 

“Really, doc? We thought we had a major issue” said the wife.

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Fertility Forum : 6th January 2018

by Dr Agilan Arjunan, Fertility Specialist & Gynaecologist, KL Fertility Centre ( Malaysia)

My next fertility forum is on 6th January 2018 , at KL Fertility .

It starts by 2.30pm .

In this free fertility forum , I’ll be focusing on a questions asked by nearly all couple : “When to start IUI or IVF ? ” .

See you all during the forum .