Higher IVF Pregnancy Success Possible?


by Dr Agilan Arjunan, Fertility Specialist, KL Fertility Centre ( Malaysia)

IVF treatment , even though undeniably had and is helping many couples to conceive , it is still a rather ‘complicated’ treatment option in the mind of a patient. It is because IVF treatment involves taking medications in the form of injections which need to be taken daily with the correct dosage. The medications are intended to grow more eggs in  a woman’s ovaries. Naturally a woman makes only one egg per menstrual cycle.

For any fertility doctor, the most dreaded complication of IVF is OHSS ( Ovarian HyperStimulation Syndrome). This happens because the many eggs that are growing releases chemical substances which can make a woman unwell. Some studies had blamed the ‘triggger’ medication used to mature the eggs prior to egg collection. The commonly used medication is hCG (human chorionic gonadotrophin). Hence new drugs has been developed to do this ‘triggering’ job. One such drug that been around for some time is called GnRH agonist.

Recently, researchers had found another candidate to fill the post of a ‘trigger’. This new candidate is a hormone called kisspeptin. Researchers had given differing dosages to trigger the maturation of the eggs prior to egg collection. The end results was excellent. There were no OHSS and what is more interesting is that the pregnancy rates are higher than a conventional IVF ! However, more larger studies are required to confirm these exciting findings.

You can read the original article here:


Achieving Higher IVF Pregnancy Success

by Dr.Agilan Arjunan, Fertility Specialist , KL Fertility Centre ( Malaysia) 

IVF technology has been around for over 30 years. It had helped many couples to realise their dreams. At last miracle is not impossible for couples with infertility. However , IVF is not a 100% solution for all. We know now that we are still unable to reverse the effect of female age on her fertility. A woman’s fertility declines as she ages. The same is true for a man and male infertility in increasing.

Continue reading “Achieving Higher IVF Pregnancy Success”

Stressful Sperms


by Dr Agilan Arjunan, Fertility Specialist, KL Fertility Centre ( Malaysia)

Screen Shot 2015-10-21 at 8.40.24 AM
Stressful Sperms

For over 30 years, scientists all around the world had found some link between stress and sperm quality. However , many of these studies were either not large enough to give a concrete conclusion or used many different methods of ‘stress level’ assessments (i.e. from self-reported stress level to reporting acute stress events). This differences in study designs made comparison among the studies or even ‘pooled-data’ analysis from all these studies not practical.

Continue reading “Stressful Sperms”

Human Genetic Modification : IVF Saviour?

by Dr Agilan Arjunan, Fertility Specialist, KL Fertility Centre ( Malaysia)

Since the beginning of field of medicine, from the ancient Egyptian to Babylonians to the Greeks, we have always tried to find the cure for many diseases. Modern medicine has advanced so much so as to be able to read the core building blocks of human beings called DNA (deoxyribonucleic acid).

DNA was first discovered and isolated by Friedrich Miescher in 1869. In 1953, James Watson and Francis Crick put forward the double-helix model of DNA which had changed the understanding of the world about DNA. According to the model, DNA is composed of basepairs .

DNA is our basic genetic material that signals the body to develop and function as it should be. DNA contains our biological information . It is passed down from one generation to the next. Health and sickness of a person is determined by their genetics or DNA. Hence, it is not surprising that recent researches looking for cure for many diseases is focused on DNA.

Continue reading “Human Genetic Modification : IVF Saviour?”

The Future of Male Infertility


by Dr Agilan Arjunan, Fertility Specialist , KL Fertility Centre (Malaysia) 

Male factor is the cause for about 1/3 of infertility. However, the role of male- cause infertility is in the rise and many researches has confirmed this fact. Nevertheless, male partner is often the “forgotten” partner in the equation of fertility treatment. The focus has always been the female. Hence, we see today many investigations and treatments are focused on the female.

To conceive a baby, we need female egg (oocyte), male sperm and a healthy womb (uterus). In the treatment of male-cause infertility, sperm is usually retrieved either my masturbation (in mild -moderate male infertility) or by a surgical procedure (in severe male infertility). In the event the sperm in not retrieved, donor sperm is advised. The next step is usually IVF/ICSI (In-Vitro Fertilisation / Intra-Cytoplasmic Sperm Injection) or sometimes IUI (Intrauterine Insemination) with donor sperm. Treatment for the couple is highly dependent on the availability of mature sperm, either from the partner or from a donor.

Continue reading “The Future of Male Infertility”

%d bloggers like this: