Fertility Genetics Simplified

by Dr Agilan Arjunan, Fertility Specialist & Gynaecologist , KL Fertility Centre ( Malaysia)

The science involved in the treatment of infertility has rapidly advanced in the past few years . This advancement is clearly seen in the field of In-Vitro Fertilisation or IVF.

Current technology enables us to look into the genetics of human reproduction. Genetic testing also provides answers to infertility; and in some cases solutions.

Preimplantation Genetic Screening ( PGS)

IVF involves creating embryos in an IVF laboratory and replacing the embryo/embryos back into the womb.

Traditionally an embryo is graded based on its morphology ( external appearance under a microscope). The embryo/embryos with the best gradings is/are transferred back into the womb.

A morphologically-normal embryo with the best grading does not necessarily indicate that the embryo is genetically normal ( euploid embryo).

A genetically-normal embryo will lead to a successful pregnancy , assuming there are no other factors contributing to a failed embryo implantation or pregnancy.

Preimplantation genetic diagnosis (PGS) looks at the genetic normality of the embryo prior to an embryo transfer procedure.

Embryos are typically grown up to 3 to 6 days before the biopsy is performed.

Biopsy of the embryos are done when the embryo is either 3 days old or when they have reached Day 5 or 6 , known as a blastocyst.

Biopsy of the blastocyst is usually preferred because more cells are obtained from the embryo thus increasing the chances of the PGS to be performed successfully.

To be able to perform the biopsy, a small opening is made on the outer layer of the embryo , using either mechanical, chemical or laser technology.

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Male Infertility : Astro VBuzz

by Dr Agilan Arjunan , Fertility Specialist & Gynaecologist, KL Fertility Centre ( Malaysia)

 

Watch my interview on Astro VBuzz  on male infertility. This interview in done in conjunction with Movember (Male health month in November).

Link : https://www.youtube.com/watch?v=OEj8W7f4E3Y

Fertility Forum : Men’s Health & Fatherhood

by Dr Agilan Arjunan, Fertility Specialist & Gynaecologist , KL Fertility Centre ( Malaysia)

 

Journey towards parenthood is shared equally by both partners. At times, the problems encountered are not related to the women alone.

This public forum aims to understand and explore common health issues related to men in achieving parenthood.

We will share with you issues related to men’s health and how it can be solved.

We hope this will bring you closer to your dreams of holding your little one in your hands…

See you soon!

Older Father Produce Smarter Kid

by Dr Agilan Arjunan , Fertility Specialist & Gynaecologist, KL Fertility Centre (Malaysia)

For many years we have known the importance of age and female fertility . A woman’s chances to get pregnant decline with advancing age.

As for men, we used to think that he can reproduce as long as he can produce sperm. That’s not the entire truth. Men’s fertility also decline with age. However, the decline is much more subtle.  In the last 5-10 years , we are seeing a rapid decline in male fertility , i.e. the sperm quantity and quality is poorer even in a younger men.

In my daily practice, I too have noticed the same trend in male fertility.

Scientific research over the last decade has shown that children born to older men has higher risk of certain condition such as autism and schizophrenia. This again reminds us that men should not delay his first child.

Interestingly , a recent research found that older men maybe can produce smarter kids! When the researchers looked at relationship between father’s age and certain features in their son, they noticed that older father’s have a more ‘intelligent’ sons.

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Fertility Tests Simplified

by Dr Agilan Arjunan , Fertility Specialist , KL Fertility Centre (Malaysia)

Have you ever gone through a fertility assessment before?

For those who had done it , you know that it can initially look very complicated with all those internal ultrasound scans, blood tests, x-ray tests and sperm test. For those who have not, rest easy as all those tests are simplified for you.

Fertility test are divided into 2 , tests for female and test for male partner.

For a man , the most important test is a semen analysis (sperm test). About a third of couples has a major problem with the male partner and thus it is very important to do this test.

“A 70 year old man can still reproduce, so this can’t be a major issue right?” . Its yes and a no. It is true that a man continues to produce sperm but the QUALITY of the sperm deteriorates as he ages. Low sperm quality equals to low chance to conceive.

What is looked for in a sperm test ?  

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